The specifics of CpG islets methylation of some genes of peripheral blood T-lymphocytes in breast cancer patients before and after treatment

Introduction . The growth of primary breast tumor morbidity in the last ten years and increased number patients with disseminated cancer Republic Kazakhstan require search for methods early diagnosis malignant tumors. Determination markers epigenetic studies allows to use them as diagnostic signs presence predictors treatment effectiveness this pathology. Aim To perform a therapeutic prognostic markers. Materials study included samples biological material (peripheral blood) 50 deemed healthy individuals 103 locally advanced receiving special therapy. following were used: blood collection, DNA extraction, creation methylation profiles, sequencing, statistical data analysis. Results results mutations peripheral showed their role specific diagnostic, specificity 0.91 % sensitivity 0.94 %. hypothesis on significance identified earlier cancer, namely hypermethylation CpG islands associated genes JAM3, C17orf64, MSC, C7orf51 island intragene part chromosome 5 (chr5: 77,208,034–77,329,434) was tested confirmed. Conclusion A correlation between characteristics disease progression during shown. can be used clinical practice: markers, such islets genes, islet intragenic site cancer.